Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC
- 作者：Cornelius F.H. Mueller ; Kerstin Wassmann ; Anja Berger ; Stefan Holz ; Sven Wassmann ; Georg Nickenig
- 关键词：AT1 receptor ; Renin– ; angiotensin system ; Calreticulin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2008
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：13 June 2008
- 卷：370
- 期：4
- 页码：669-674
- 文件大小：276 K
摘要
The AT1 receptor plays a pivotal role for the pathogenesis of hypertension and atherosclerosis. AT1 receptor expression is regulated posttranscriptionally via destabilization of the AT1 receptor mRNA by mRNA binding proteins. Recently, we identified calreticulin as a novel binding protein within the 3′untranslated region of the AT1 receptor mRNA.