- 作者：Chuan Li ; Kai Mi ; Tian fu Wen ; ccwentianfu@sohu.com ; Lu nan Yan ; Bo Li ; Jia ying Yang ; Ming qing Xu ; Wen Tao Wang ; Yong gang Wei
- 关键词：BMI ; body mass index ; HBV ; hepatitis B virus ; HCV ; hepatitis C virus ; INR ; international normalised ratio ; GRWR ; graft to recipient body weight ratios ; LDLT ; living donor liver transplantation ; MELD ; model for end-stage liver disease ; MHV ; middle hepatic
- 刊名：Digestive and Liver Disease
- 出版年：2012
- 期刊代码：79_15908658
- 类别：med
- 出版时间：July, 2012
- 卷：44
- 期：7
- 页码：597-602
- 文件大小：377 K
Background
The number of living donor liver transplantations performed has increased rapidly in many Eastern transplant centres. However, the impact of the transplant centres鈥?experience and learning on the transplant outcomes are not well established. Aim of the study was to evaluate the learning curve for living donor liver transplantation in our centre.Methods
Data from 156 recipients and 156 donors who underwent surgery were reviewed. Intraoperative data and postoperative outcomes of both donors and recipients were retrospectively analysed. Recipients and donors were divided into three groups that consisted of 52 consecutive cases each.
Results
Surgical duration and intraoperative blood loss during donor surgery were decreased significantly between the earlier and the more recent cases (423 卤 39 vs. 400 卤 44 min and 959 卤 523 vs. 731 卤 278 mL, respectively; P < 0.01). Rates of postoperative complications and functional changes were not statistically different amongst the three donor groups. Immediate complication rate of the first 52 recipients was higher than those of the second and third cohorts. Long-term survival rates of the three recipient groups were similar.
Conclusions
The learning curve greatly influenced immediate outcomes of recipients during the early transplant period. However, it had little influence on donor outcome; long-term outcome improvement of recipients did not depend on the accumulation of experience alone.