The antifungal constituents from the seeds of Itoa orientalis

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• 作者：WenWei Tang^a ; ^{wenweit@yahoo.com.cn} ; HanHong Xu^b ; DongQiang Zeng^a ; ^{zengdq550@163.com} ; LiJia Yu^a
• 关键词：New phenolic constituents ; Antifungal activity ; Itoa orientalis
• 刊名：Fitoterapia
• 出版年：2012
• 期刊代码：35_0367326x
• 类别：ch
• 出版时间：April, 2012
• 卷：83
• 期：3
• 页码：513-517
• 文件大小：317 K

摘要

Three new phenolic constituents, itolide A (1), itolide B (2), itoside P (3), and 1D-3-deoxy-3-hydroxymethyl-myo-inositol (4), which is described herein for the first time as a natural product, were isolated along with four other known compounds (5 to 8) from the methanol extract of the seeds of Itoa orientalis Hemsl by the activity-guided fractionation. Their structures were determined by spectroscopic means. Compounds 1 to 8 exhibited antifungal activities against Sclerotium rolfsii with IC₅₀ values ranging from 60.12 to 240.00 渭M and against Rhizoctonia solani with IC₅₀ values ranging from 45.34 to 233.14 渭M, respectively, and compounds 1, 2, 5 exhibited cytotoxic activity against Tn5B1-4 insect cell line with EC₅₀ values of 203.68, 93.41 and 40.37 渭M, respectively.