Lateralized and focal clinical, EEG, and FLAIR MRI abnormalities in Creutzfeldt–Jakob disease

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• 作者：Cambier ; Denise M. ; Kantarci ; Kejal ; Worrell ; Gregory A. ; Westmoreland ; Barbara F. ; Aksamit ; Allen J.
• 关键词：Search headings ; Cognitive disorder/dementia ; Creutzfeldt&ndash ; Jakob ; Electroencephalography ; Magnetic resonance imaging ; Neuroimaging
• 刊名：Clinical Neurophysiology
• 出版年：2003
• 期刊代码：61_13882457
• 类别：med
• 出版时间：September, 2003
• 卷：114
• 期：9
• 页码：1724-1728
• 文件大小：178 K

摘要

Objective: Creutzfeldt–Jakob disease (CJD) is a rapidly progressive fatal prion disorder with typical clinical findings of dementia, motor dysfunction, and myoclonus and characteristic electroencephalographic (EEG) findings of bilateral synchronous periodic sharp waves. Advances in neuroimaging capabilities with diffusion-weighted and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) techniques have shown promise in the non-invasive diagnosis of CJD. This series illustrates the correlation between the lateralized and focal clinical, EEG, and MRI FLAIR sequence abnormalities in 8 patients (7 men and one woman 55–73 years old) with CJD.