Automatic white matter lesion segmentation using an adaptive outlier detection method

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• 作者：Kok Haur Ong^a ; ^{kokhaur@cs.usm.my} ; Dhanesh Ramachandram^a ; ^{dhaneshr@cs.usm.my} ; Rajeswari Mandava^a ; ^{mandava@cs.usm.my} ; Ibrahim Lutfi Shuaib^b ; ^{Ibrahim@amdi.usm.edu.my}
• 关键词：MRI ; Outlier ; White matter lesions ; White matter hyperintensities ; Leukoaraiosis ; Adaptive trimmed mean algorithm ; Box&ndash ; whisker plot
• 刊名：Magnetic Resonance Imaging
• 出版年：2012
• 期刊代码：188_0730725x
• 类别：med
• 出版时间：July, 2012
• 卷：30
• 期：6
• 页码：807-823
• 文件大小：1779 K

摘要

White matter (WM) lesions are diffuse WM abnormalities that appear as hyperintense (bright) regions in cranial magnetic resonance imaging (MRI). WM lesions are often observed in older populations and are important indicators of stroke, multiple sclerosis, dementia and other brain-related disorders. In this paper, a new automated method for WM lesions segmentation is presented. In the proposed method, the presence of WM lesions is detected as outliers in the intensity distribution of the fluid-attenuated inversion recovery (FLAIR) MR images using an adaptive outlier detection approach. Outliers are detected using a novel adaptive trimmed mean algorithm and box-whisker plot. In addition, pre- and postprocessing steps are implemented to reduce false positives attributed to MRI artifacts commonly observed in FLAIR sequences. The approach is validated using the cranial MRI sequences of 38 subjects. A significant correlation (R=0.9641, P value=3.12脳10^鈭?) is observed between the automated approach and manual segmentation by radiologist. The accuracy of the proposed approach was further validated by comparing the lesion volumes computed using the automated approach and lesions manually segmented by an expert radiologist. Finally, the proposed approach is compared against leading lesion segmentation algorithms using a benchmark dataset.