Role of B-Type Natriuretic Peptide and Effect of Nesiritide After Total Cardiac Replacement With the AbioCor Total Artificial Heart

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• 作者：Reynolds Delgado III ; Yasmin Wadia ; Biswajit Kar ; Whitson Ethridge ; Aly Zewail ; Toni Pool ; Timothy J. Myers ; Nancy Scroggins and O.H. Frazier
• 刊名：The Journal of Heart and Lung Transplantation
• 出版年：2005
• 期刊代码：161_10532498
• 类别：med
• 出版时间：2005
• 卷：24
• 期：8
• 页码：1166-1170
• 文件大小：116 K

摘要

Endogenous B-type natriuretic peptide (BNP) is thought to be produced in the cardiac ventricles. After sub-total cardiectomy and implantation of a total artificial heart (TAH), the abrupt withdrawal of BNP impairs renal function despite normal hemodynamic variables. We hypothesized that abrupt withdrawal of endogenous BNP may impair renal function and volume homeostasis and BNP may have a direct renal influence unrelated to its cardiovascular effect. Nesiritide infusion should be supplemented in the interim and weaned slowly until BNP levels normalize, which suggests that BNP is produced in tissues other than the cardiac ventricles.