The comparison of platelet activity between patients with patent vs. occluded coronary artery bypass grafts

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• 作者：Pavel P. Osmancik ; Frantisek Bednar ; Heidi Mó ; ciková ; Petr Stros ; Karel Jirasek ; Zbynek Straka ; Petr Widimsky
• 关键词：Platelet ; P-selectin ; Aggregometry ; Flow cytometry ; Bypass graft ; Coronary artery disease ; Coronary surgery
• 刊名：Thrombosis Research
• 出版年：2007
• 期刊代码：247_00493848
• 类别：med
• 出版时间：2007
• 卷：120
• 期：4
• 页码：523-529
• 文件大小：190 K

摘要

Arterial calcification is associated with increased risk of cardiovascular events. Osteoprotegerin (OPG) is a cytokine involved in the bone metabolism and vascular calcification. Recent data support a relationship between high serum levels of OPG and increased risk for cardiovascular disease in human. The aim of this study was to evaluate the OPG serum levels in acute ischemic stroke. Our study was further designed to detect differences in serum OPG levels between subtypes of ischemic stroke.

Materials and methods

The study consisted of 51 patients with acute ischemic stroke and 28 control subjects. Stroke subtypes were defined by the TOAST classifications. Serum OPG levels were measured with the ELISA method.

Results

OPG serum levels were significantly higher in patients with ischemic stroke than in control subjects (p < 0.001). OPG serum levels were significantly higher in large-vessel disease (LVD) subtype compared with small-vessel disease (SVD) subtype and controls (p < 0.001, p < 0.001). There was no significant difference in OPG serum levels between SVD group and control subjects. Serum OPG levels were correlated with age (r = 0.407, p = 0.005) and fasting glucose levels (r = 0.542, p = 0.001) in ischemic stroke group. Logistic regression analysis showed that plasma OPG levels (OR 2.1, 95%CI, 1.16 to 3.4, p = 0.01) associated with presence of stroke independently of the other risk factors.

Conclusions

High serum OPG levels were associated with the LVD stroke subtype, suggesting that OPG levels may play role in pathogenesis of atherothrombotic stroke. The precise mechanism for the role of OPG in atherosclerosis needs to be investigated further.