Evidence that the COMTp>Val158Metp> polymorphism moderates subclinical psychotic and affective symptoms in unaffected first-degree relatives of patients with schizophrenia

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• 作者：Ruud van Winkel ; Pilar Isusi ; Paloma Galdos ; Elena Echevarria ; José ; Ram&#xf3 ; n Bilbao ; Ainhoa Martin-Pagola ; Luis Casta&#xf1 ; o ; Sergi Papiol ; Ron Mengelers ; Lydia Krabbendam ; Jim van Os ; Inez Myi
• 关键词：COMT ; Schizophrenia ; Psychosis ; Affective symptoms
• 刊名：European Psychiatry
• 出版年：2008
• 期刊代码：96_09249338
• 类别：med
• 出版时间：April 2008
• 卷：23
• 期：3
• 页码：219-222
• 文件大小：135 K

摘要

Psychotic patients with COMTp>Val158Metp> Met alleles were recently found to display more intense psychotic and affective responses to daily life stressors. We aimed to test the hypothesis that the Met allele is implicated in the development of affective and psychotic symptomatology in subjects genetically at risk for schizophrenia, by testing if unaffected first-degree relatives of patients with schizophrenia who share a Met allele have greater concordance of symptomatology than relatives not sharing a Met allele.