In vivo inhibition of E. coli growth by a Ru(II)/Pt(II) supramolecule [(tpy)RuCl(dpp)PtCl₂](PF₆)

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• 作者：Avijita Jain ; Brenda S.J. Winkel ; Karen J. Brewer
• 关键词：Cisplatin ; Anti-cancer agents ; In vivo activity ; Mixed metal supramolecular complexes ; Anti-bacterial activity
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2007
• 期刊代码：53_01620134
• 类别：ch
• 出版时间：October 2007
• 卷：101
• 期：10
• 页码：1525-1528
• 文件大小：247 K

摘要

Supramolecular complexes consisting of ruthenium chromophores and a cisplatin unit represent an emerging class of bioactive molecules of interest as anti-cancer agents. Although the ability of Ru(II)/Pt(II) heteronuclear complexes to bind to DNA has been demonstrated, the in vivo activity of these complexes has not yet been reported. In the present work, we report the anti-bacterial activity of the complex [(tpy)RuCl(dpp)PtCl₂](PF₆) (where dpp = 2,3-bis(2-pyridyl)pyrazine, tpy = 2,2′:6′,2′′-terpyridine). The impact on bacterial cell growth of exposure to different concentrations of [(tpy)RuCl(dpp)PtCl₂](PF₆) and cisplatin was studied. The bioactivity of this complex was found to be due to the presence of the cis-PtCl₂ moiety, as the monometallic synthon [(tpy)RuCl(dpp)](PF₆) did not inhibit bacterial cell growth.