Efficacy of a targeted cognitive-behavioral treatment program for cannabis use disorders (CANDIS*)

详细信息	查看全文 | 推荐本文 |

• 作者：E. Hoch ; R. Noack ; J. Henker ; A. Pixa ; M. H&ouml ; fler ; S. Behrendtup> ; up>up>silke.behrendt@psychologie.tu-dresden.deup> ; G. B&uuml ; hringer ; H.-U. Wittchen
• 关键词：Cannabis use disorders ; Cognitive&ndash ; behavioral therapy ; Motivational enhancement ; Psychosocial problem solving ; RCT
• 刊名：European Neuropsychopharmacology
• 出版年：2012
• 期刊代码：95_0924977x
• 类别：med
• 出版时间：April, 2012
• 卷：22
• 期：4
• 页码：267-280
• 文件大小：533 K

摘要

Aims

To examine the efficacy, 3- and 6-month follow-up effects of a psychological treatment for older adolescents and adults with DSM-IV cannabis use disorders. The program was tailored to the needs of this patient population.

Experimental procedures

A randomized controlled clinical trial of 122 patients aged 16 to 44 years with DSM-IV cannabis dependence as the main substance use diagnosis was conducted. Patients were randomly assigned to either Active Treatment (AT, n = 90) or a Delayed Treatment Control group (DTC, n = 32). Treatment consisted of 10 sessions of therapy, detailed in a strictly enforced manual. Assessments were conducted at baseline, during each therapy session, at post treatment and at follow-up assessments at 3 and 6 months.

Results

The treatment retention rate was 88%. Abstinence was achieved in 49%of AT patients and in 13%of those in DTC (p < 0.001; intend-to-treat (ITT) analysis). Further, AT patients improved significantly (p < = 0.001) in the frequency of cannabis use per week, addiction severity, number of disability days, and overall level of psychopathology. Program effects were maintained over a 3-month- (abstinence rate: 51%) and 6-month follow-up (45%) period.

Conclusion

The treatment program is effective in obtaining abstinence as well as reducing cannabis use and improves the associated social and mental health burden.