c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2

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• 作者：Petr Vaň ; hara ; Ví ; t&#x11b ; zslav Bryja ; Viktor Horvá ; th ; Alois Kozubí ; k ; Aleš ; Hampl ; Jan Š ; marda
• 关键词：Jun ; Cyclin A ; CDK2 ; Apoptosis ; v-myb-transformed monoblasts
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2007
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：2 February 2007
• 卷：353
• 期：1
• 页码：92-97
• 文件大小：321 K

摘要

c-Jun is one of the major components of the activating protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation, and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery, and programmed cell death pathway in leukemic cells.