ERα, but not ERβ, mediates the expression of sexual behavior in the female rat
- 作者：Christine A. Mazzucco ; Hope A. Walker ; Jodi L. Pawluski ; Stephanie E. Lieblich ; Liisa A.M. Galea
- 关键词：Lordosis ; Female sexual behavior ; ER agonists ; Proceptivity ; Receptivity ; Estrogen receptors ; Rat ; ER
//www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> ; ERβ
- 刊名：Behavioural Brain Research
- 出版年：2008
- 期刊代码：3_01664328
- 类别：neu
- 出版时间：5 August 2008
- 卷：191
- 期：1
- 页码：111-117
- 文件大小：347 K
摘要
Estrogen has well known effects on sexual behavior, however the role of the estrogen receptors (ER) 
er alpha" title="greek small letter alpha" border="0"> and β on sexual behavior remains to be fully determined. This study investigated the individual and co-operative involvement of ERer alpha" title="greek small letter alpha" border="0"> and β on sexual behaviors in the adult female rat. Subtype selective ER agonists, propyl-pyrazole triol (PPT; ERer alpha" title="greek small letter alpha" border="0"> agonist) and diarylpropionitrile (DPN; ERβ agonist) were utilized to examine each receptor subtype's contribution, individual and co-operative, for both receptive (lordosis) and proceptive (hopping/darting, ‘ear wiggling’) female sexual behaviors. Ovariectomized female rats received subcutaneous injections of either: sesame oil (OIL), dimethylsulfoxide (DMSO), estradiol benzoate (EB; 10 μg/0.1 ml OIL), one of three doses of the ERer alpha" title="greek small letter alpha" border="0"> agonist PPT (1.25 mg, 2.5 mg or 5.0 mg/0.1 ml DMSO), one of three doses of the ERβ agonist DPN (1.25 mg, 2.5 mg or 5.0 mg/0.1 ml DMSO) or a combination dose of PPT and DPN (2.5 mg PPT + 2.5 mg DPN/0.1 ml DMSO) for two consecutive days, 48 and 24 h prior to testing followed by a progesterone injection (500 μg/0.1 ml OIL) 4 h prior to testing in order to elicit sexual behavior. The ERer alpha" title="greek small letter alpha" border="0"> agonist PPT, but not the ERβ agonist DPN, elicited both proceptive and receptive behavior. PPT at doses of 2.5 and 5.0 mg significantly elicited lordosis and proceptive behavior (‘ear wiggling’, hopping and darting). Intriguingly, the administration of both agonists together at the 2.5 mg dose resulted in reduced levels of proceptivity and receptivity, suggesting that ERβ modulates ERer alpha" title="greek small letter alpha" border="0">'s ability to elicit receptive and proceptive sexual behavior.
er alpha" title="greek small letter alpha" border="0"> and β on sexual behavior remains to be fully determined. This study investigated the individual and co-operative involvement of ERer alpha" title="greek small letter alpha" border="0"> and β on sexual behaviors in the adult female rat. Subtype selective ER agonists, propyl-pyrazole triol (PPT; ERer alpha" title="greek small letter alpha" border="0"> agonist) and diarylpropionitrile (DPN; ERβ agonist) were utilized to examine each receptor subtype's contribution, individual and co-operative, for both receptive (lordosis) and proceptive (hopping/darting, ‘ear wiggling’) female sexual behaviors. Ovariectomized female rats received subcutaneous injections of either: sesame oil (OIL), dimethylsulfoxide (DMSO), estradiol benzoate (EB; 10 μg/0.1 ml OIL), one of three doses of the ERer alpha" title="greek small letter alpha" border="0"> agonist PPT (1.25 mg, 2.5 mg or 5.0 mg/0.1 ml DMSO), one of three doses of the ERβ agonist DPN (1.25 mg, 2.5 mg or 5.0 mg/0.1 ml DMSO) or a combination dose of PPT and DPN (2.5 mg PPT + 2.5 mg DPN/0.1 ml DMSO) for two consecutive days, 48 and 24 h prior to testing followed by a progesterone injection (500 μg/0.1 ml OIL) 4 h prior to testing in order to elicit sexual behavior. The ERer alpha" title="greek small letter alpha" border="0"> agonist PPT, but not the ERβ agonist DPN, elicited both proceptive and receptive behavior. PPT at doses of 2.5 and 5.0 mg significantly elicited lordosis and proceptive behavior (‘ear wiggling’, hopping and darting). Intriguingly, the administration of both agonists together at the 2.5 mg dose resulted in reduced levels of proceptivity and receptivity, suggesting that ERβ modulates ERer alpha" title="greek small letter alpha" border="0">'s ability to elicit receptive and proceptive sexual behavior.