• 作者：José ; Miguel Baena-Dí ; ez^a ; ^b ; ^c ; ^{jbaenad@meditex.es} ; Noemí ; Bermú ; dez-Chillida^a ; Xavier Mundet^b ; ^d ; ^e ; ^f ; José ; Luis del Val-Garcí ; a^b ; ^e ; Miguel Angel Mu&#241 ; oz^b ; ^e ; ^f ; Helmut Schrö ; der^g
• 关键词：Intolerancia a la glucosa ; Glucemia basal alterada ; Diabetes mellitus tipo 2 ; Obesidad ; Historia natural ; Diagnó ; stico
• 刊名：Medicina Cl铆nica
• 出版年：2011
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：9 April 2011
• 卷：136
• 期：9
• 页码：382-385
• 文件大小：200 K

Background and objective

The aim of this study was to define the incidence of type 2 diabetes mellitus in patients with impaired fasting glucose and its association with risk factors.

Patients and method

115 patients aged > 18 years old, randomly selected in a Healthcare Center, diagnosed of impaired fasting glucose with 1997 American Diabetes Association criteria, followed 10 years. Predictive factors for developing diabetes mellitus were: age, sex, smoking, hypertension, hypercholesterolemia, family history of type 2 diabetes mellitus, antecedent of diabetes in pregnancy, and obesity.

Results

During the 10 years of follow-up, 33 patients developed type 2 diabetes mellitus (28.7%; 95%CI 20.4-37.0%), 57 patients progressed to normoglycaemia (49.6%; 95%CI 40.4-58.7%), and 25 patients remained with an impaired fasting glucose (21.7%; 95%CI 14.2-29.3%). Only obesity was associated with progression to type 2 diabetes mellitus (adjusted hazard ratio 2.01; 95%CI 1.00-4.03, p = 0.050).

Conclusions

Half of the patients with impaired fasting glucose normalized their glycaemia, and 28.7%developed diabetes mellitus, especially patients with obesity. These results suggest a different natural history to respect glucose intolerance.