In vitro assays that measure the
interferon gamma product
ion by T cells
incubated w
ith spec
if
ic ant
igen of
Mycobacterium tuberculosis may be useful
in the d
iagnos
is of tuberculos
is
in ch
ildren. Compared to Mantoux test, these tests are eas
ier to perform and ha
ve a greater spec
if
ic
ity, espec
ially because they do not cross-react w
ith BCG
vacc
ine and w
ith most of en
vironmental Mycobacter
ia. Howe
ver, the
ir sens
it
ivity
is not well e
valuated
in ch
ildren. To date
in ped
iatr
ics, they can be assoc
iated w
ith Mantoux test for the d
iagnos
is of act
ive tuberculos
is. In the d
iagnos
is of latent tuberculos
is
infect
ion, larger stud
ies w
ith commerc
ial k
its are requ
ired.iv>iv>
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