GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine

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• 作者：Mert D&#xf6 ; ş ; kaya ; Mina Kalantari-Dehaghi ; Craig M. Walsh ; Elż ; bieta Hiszczyń ; ska-Sawicka ; D. Huw Davies ; Philip L. Felgner ; Liza S.Z. Larsen ; Richard H. Lathrop ; G. Wesley Hatfield ; J
• 关键词：Toxoplasma gondii ; GRA1 ; Codon-optimization ; DNA vaccination ; Adjuvanted recombinant protein vaccination
• 刊名：Vaccine
• 出版年：2007
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：26 February 2007
• 卷：25
• 期：10
• 页码：1824-1837
• 文件大小：617 K

摘要

The present study evaluates immunogenicity and protection potency of a codon-optimized GRA1 DNA vaccine, wild type GRA1 DNA vaccine and an adjuvanted recombinant GRA1 protein vaccine candidate in BALB/c mice against lethal toxoplasmosis. Of the three GRA1 vaccines tested, the recombinant GRA1 protein vaccine results reveal significant increase in immune response and prolonged survival against acute toxoplasmosis compared to DNA vaccinations. Immune response and protection conferred by codon-optimized GRA1 DNA vaccine was slightly better than wild type GRA1 DNA vaccine.