Serum DcR3 level in 118 healthy controls, 24 sepsis patients and 43 SIRS patients, was quantitatively measured by enzyme-linked immunosorbent assay (ELISA).
The serum DcR3 was significantly increased in sepsis patients compared with SIRS patients and healthy controls (6.11 卤 2.58 ng/ml vs 2.62 卤 1.46 ng/ml, and 0.91 卤 0.56 ng/ml, respectively, p < 0.001). The areas under the receiver operating characteristic curve of DcR3 for the normal vs. SIRS, normal vs. sepsis and SIRS vs. sepsis were 0.910 (0.870-0.950), 0.992 (0.984-1.000) and 0.896 (0.820-0.973), respectively. In addition, the DcR3 exhibited a positive correlation coefficient with APACHE II score, a most commonly used index for the severity of sepsis (r = 0.556, p = 0.005).
The serum DcR3 has a potential to serve as a new biomarker for sepsis with its high specificity and sensitivity.