The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population

详细信息	查看全文 | 推荐本文 |

• 作者：Qinling Wei^a ; ^b ; ¹ ; Feici Diao^a ; ¹ ; Zhuang Kang^c ; Zhaoyu Gan^a ; Zili Han^a ; Liangrong Zheng^a ; Leijun Li^a ; Xiaofeng Guo^b ; Baoci Shan^d ; Chunlei Liu^e ; ^f ; Jingping Zhao^b ; ^{zhaojingpingcsu@163.com} ; Jinbei Zhang^a ; ^{weiql.yuelu@yahoo.com.cn}
• 关键词：GM ; gray matter ; OFC ; orbitofrontal cortex ; ROI ; regions of interesting ; SZ ; schizophrenia ; PFH ; positive family history ; NFH ; negative family history
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：23 May, 2012
• 卷：517
• 期：1
• 页码：21-24
• 文件大小：309 K

摘要

Schizophrenia is thought to arise in part from abnormal gray matter (GM), which are partly shared by the relatives of the probands. DISC1 is one of the most promising susceptibility genes of schizophrenia and a SNP rs821597 (A) in the gene was associated with schizophrenia in Han Chinese population. In this study, 61 healthy controls and 72 with schizophrenic patients were genotyped at rs821597, and underwent T1-weighted MRI for the density of GM. The results showed that the risk allele (A) carriers had higher GM density in regional left parahippocampal gyrus and right orbitofrontal cortex in schizophrenic patients, but had reduced GM density of these brain regions in healthy controls. The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional GM in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia.