Effects of quinestrol on reproductive hormone expression, secretion, and receptor levels in female Mongolian gerbils (Meriones unguiculatus)

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• 作者：Xiaohui Lv^a ; Y. Guo^b ; D. Shi^a ; ^{lvxiaohuiandshi@163.com}
• 关键词：Mongolian gerbils ; Quinestrol ; Reproductive hormone receptor ; Reproductive hormones
• 刊名：Theriogenology
• 出版年：2012
• 期刊代码：98_0093691x
• 类别：abs
• 出版时间：1 April, 2012
• 卷：77
• 期：6
• 页码：1223-1231
• 文件大小：1219 K

摘要

Quinestrol, a synthetic estrogen with marked estrogenic effects and prolonged activity, has potential as a contraceptive for Mongolian gerbils. The objective of this study was to describe the effects of quinestrol on reproductive hormone expression, secretion, and receptor levels in female Mongolian gerbils. Serum and pituitary concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were decreased, whereas serum concentrations of estradiol (E2) and progesterone (P4) were increased after quinestrol treatment; the effects were both time- and dose-dependent. Furthermore, quinestrol downregulated expression of FSH尾 and LH尾 mRNA in the pituitary gland, as well as FSH receptor (FSHR) and estrogen receptor (ER) 尾 in the ovary. However, it up-regulated mRNA expression levels of ER伪 and progesterone receptor (PR) in the pituitary gland and uterus, as well as mRNA for LH receptor (LHR) and PR in the ovary (these effects were time- and dose-dependent). In contrast, quinestrol had no significant effects on the mRNA expression levels of ER伪 in the ovary, or the gonadotropin 伪 (GtH伪) subunit in the pituitary gland. We inferred that quinestrol impaired synthesis and secretion of FSH and LH and that the predominant ER subtype in the pituitary gland of Mongolian gerbils may be ER伪. Overall, quinestrol disrupted reproductive hormone receptor expression at the mRNA level in the pituitary-gonadal axis of the Mongolian gerbil.