Highly efficient oxidation of 2-imidazoline-5-carboxylic derivatives to聽imidazole-5-carboxylic derivatives by dioxygen

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• 作者：Yue Huang ; Xiaodong Zu ; Fan Wu ; Jinyi Xu ; Xiaoming Wu ; Hequan Yao ; ^{hyao@cpu.edu.cn}
• 关键词：Oxidation ; 2-Imidazoline ; Imidazole ; Dioxygen ; Scalable
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：8 April, 2012
• 卷：68
• 期：14
• 页码：3123-3128
• 文件大小：873 K

摘要

A highly efficient and environmental-benign oxidation by dioxygen (or air) as the sole oxidant was first applied for the conversion of 2-imidazoline-5-carboxylic derivatives to imidazole-5-carboxylic derivatives in very good and excellent yields. The substituent effect on 2-imidazoline ring was investigated. This protocol was also suitable for the synthesis of 2-imidazoles in relatively large scale.