Prolonged modulation of FGF-2 expression in astrocytic cultures induced by O,O′-diacetyl-apomorphine
- 作者：Xiaochun He ; Dakui Wang ; Xinhua Zhang ; Aiqun Li ; Xiaosong Gu ; Fei Ding ; Jiawei Zhou
- 关键词：Apomorphine ; Fibroblast growth factor-2 ; Astrocytes ; Chemical synthesis ; O ; O′ ; -Diacetyl-apomorphine
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2008
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：9 May 2008
- 卷：369
- 期：3
- 页码：824-829
- 文件大小：241 K
摘要
Apomorphine (APO) is an anti-parkinsonian drug currently in use, which provides relief of Parkinson’s symptoms. However, the utility of APO is greatly hampered by its poor bioavailability and rapid metabolism. In the present study, O,O′-diacetyl-apomorphine, a prodrug of apomorphine, was synthesized and its biological activity was examined. The prodrug induced fibroblast growth factor-2 production in astrocytic cultures similarly to apomorphine. However, its duration of action was significantly prolonged, and its resistance to oxidation was markedly enhanced compared to APO. O,O′-Diacetyl-apomorphine also induced MEK/MAPK signaling. These results suggest that O,O′-diacetyl-apomorphine can efficiently counteract oxidation and thereby enhance FGF-2 production in astrocytes.