Histamine H4 receptors regulate ACTH release in AtT-20 cells
- 作者：Jia Meng ; Xue Ma ; Mingkai Li ; Min Jia ; Xiaoxing Luo
- 关键词：Histamine H4 receptor ; JNJ 7777120 ; ACTH ; AtT-20 cell
- 刊名：European Journal of Pharmacology
- 出版年：2008
- 期刊代码：24_00142999
- 类别：neu
- 出版时间：10 June 2008
- 卷：587
- 期：1-3
- 页码：336-338
- 文件大小：292 K
摘要
The early research described that adrenocorticotropic hormone (ACTH) release from mouse pituitary tumor AtT-20 cells was regulated by histamine H3 receptors. Here, we provide the evidence that histamine H4 receptor was expressed in AtT-20 cell, and that the accelerated ACTH secretions from the cells by histamine and R-
-methylhistamine were blocked by JNJ7777120, a specific H4 receptor antagonist, in concentration dependent manner, but not by the H1 and H2 receptor antagonists. The results indicate, for the first time, that histamine H4 receptor, rather than histamine H3 receptor, played a role in regulation of ACTH release from mouse pituitary AtT-20 cells.
-methylhistamine were blocked by JNJ7777120, a specific H4 receptor antagonist, in concentration dependent manner, but not by the H1 and H2 receptor antagonists. The results indicate, for the first time, that histamine H4 receptor, rather than histamine H3 receptor, played a role in regulation of ACTH release from mouse pituitary AtT-20 cells.