Electrochemical sensor based on nitrogen doped graphene: Simultaneous determination of ascorbic acid, dopamine and uric acid

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• 作者：Zhen-Huan Sheng^a ; ^b ; Xiao-Qing Zheng^a ; Jian-Yun Xu^a ; Wen-Jing Bao^a ; Feng-Bin Wang^a ; Xing-Hua Xia^a ; ^{xhxia@nju.edu.cn}
• 关键词：Nitrogen doped graphene ; Electrochemical sensor ; Simultaneous determination ; Ascorbic acid ; Dopamine ; Uric acid
• 刊名：Biosensors and Bioelectronics
• 出版年：2012
• 期刊代码：12_09565663
• 类别：ch
• 出版时间：15 April, 2012
• 卷：34
• 期：1
• 页码：125-131
• 文件大小：643 K

摘要

Nitrogen doped graphene (NG) was prepared by thermally annealing graphite oxide and melamine mixture. After characterization by atomic force microscopy and X-ray photoelectron spectroscopy etc., the electrochemical sensor based on NG was constructed to simultaneously determine small biomolecules such as ascorbic acid (AA), dopamine (DA) and uric acid (UA). Due to its unique structure and properties originating from nitrogen doping, NG shows highly electrocatalytic activity towards the oxidation of AA, DA and UA. The electrochemical sensor shows a wide linear response for AA, DA and UA in the concentration range of 5.0 脳 10^鈭? to 1.3 脳 10^鈭? M, 5.0 脳 10^鈭? to 1.7 脳 10^鈭? M and 1.0 脳 10^鈭? to 2.0 脳 10^鈭? M with detection limit of 2.2 脳 10^鈭? M, 2.5 脳 10^鈭? M and 4.5 脳 10^鈭? M at S/N = 3, respectively. These results demonstrate that NG is a promising candidate of advanced electrode material in electrochemical sensing and other electrocatalytic applications.