Antituberculosis and cytotoxic activities of triorganotin(IV) complexes

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• 作者：Hidayat Hussain^a ; ^b ; ^{Hidayat110@gmail.com} ; Nazia Bibi^c ; ^d ; Ahmed Al-Harrasi^b ; Salman Siddiqi^e ; Shahana U. Kazmi^c ; Ying Zhang^d ; Amin Badshah^f
• 关键词：Triorganotin(IV) complexes ; Antituberculosis activity ; MICs ; Cytotoxicity
• 刊名：Chinese Chemical Letters
• 出版年：2012
• 期刊代码：3_10018417
• 类别：ch
• 出版时间：June, 2012
• 卷：23
• 期：6
• 页码：731-735
• 文件大小：267 K

摘要

Five triorganotin(IV) (1-5) complexes of cinnamic acid, (Z)-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by ¹H-¹³C-¹¹⁹Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin(IV) compounds. Five triorganotin(IV) complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to be 0.08 and 1.25 渭g/mL.