Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population
- 作者：Minhua Shao ; Hongxia Ma ; Ying Wang ; Liang Xu ; Jing Yuan ; Yi Wang ; Zhibin Hu ; Lin Yang ; Feng Wang ; Hongliang Liu ; Ji Qian ; Pengcheng Xun ; Weihong Chen ; Wentao Yuan ; Guangfu Jing ; Feng Chen ; Li Jin ; Qin
- 关键词：Molecular epidemiology ; Susceptibility ; Lung cancer ; Polymorphisms ; ERCC4 ; Nucleotide excision repair
- 刊名：Lung Cancer
- 出版年：2008
- 期刊代码：187_01695002
- 类别：med
- 出版时间：June 2008
- 卷：60
- 期：3
- 页码：332-339
- 文件大小：158 K
摘要
ERCC4/XPF protein plays an important role in the nucleotide excision repair (NER) pathway, and deficiencies in the gene encoding it can lead to a repair-deficiency syndrome, xeroderma pigmentosum group F (XP-F). Common variants on this gene are assumed to be foreboding markers for lung cancer, and 4 selected SNPs in the ERCC4 gene were genotyped in a multi-center case–control study involving 1010 lung cancer patients and 1011 cancer-free controls in a Chinese Han population to test the hypothesis. A significant association to decreased risk of lung cancer was observed in major allele C of rs3136038 carriers (adjusted OR = 0.57, 95%CI = 0.39–0.84 for CT; adjusted OR = 0.75, 95%CI = 0.52–1.10 for CC; adjusted OR = 0.68, 95%CI = 0.46–0.99 for CT + CC, compared with genotype TT), and additionally, referenced with homozygote TT, the heterozygous genotype CT showed a distinct protective effect in younger subjects (adjusted OR = 0.47, 95%CI = 0.26–0.86), in males (adjusted OR = 0.59, 95%CI = 0.37–0.93), in non-smokers (adjusted OR = 0.38, 95%CI = 0.20–0.72), in subjects without family history of cancer (adjusted OR = 0.52, 95%CI = 0.34–0.80) and in adenocarcinomas patients (adjusted OR = 0.51, 95%CI = 0.31–0.84).