Reduced cortical thickness in non-medicated patients with obsessive-compulsive disorder

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• 作者：Takashi Nakamae^a ; ^{nakamae@koto.kpu-m.ac.jp} ; Jin Narumoto^a ; Yuki Sakai^a ; Seiji Nishida^a ; Kei Yamada^b ; Manabu Kubota^c ; Jun Miyata^c ; Kenji Fukui^a
• 关键词：OCD ; obsessive-compulsive disorder ; MRI ; magnetic resonance imaging ; Y-BOCS ; Yale-Brown Obsessive-Compulsive Scale ; HDRS ; Hamilton Depression Rating Scale ; HARS ; Hamilton Anxiety Rating Scale ; 3D-MPRAGE ; three-dimensional magnetization-prepared rapid grad
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2012
• 期刊代码：222_02785846
• 类别：med
• 出版时间：27 April, 2012
• 卷：37
• 期：1
• 页码：90-95
• 文件大小：371 K

摘要

Increasing evidence suggests the presence of grey matter volume abnormalities in patients with obsessive-compulsive disorder (OCD) and the mediation of the expression of different OCD symptoms by discrete neural systems of the brain. However, limited studies have investigated the abnormalities of cortical thickness, and their results are comparatively inconsistent, possibly owing to the inclusion of medicated patients. Therefore, this study investigated cortical thickness abnormalities using surface-based analysis to identify distinct neural correlates of each symptom dimension in non-medicated patients with OCD. Thirty non-medicated patients with OCD and 30 age- and gender-matched healthy controls underwent magnetic resonance imaging. Group comparison of cortical thickness was performed using surface-based analysis. We also conducted correlation analysis between cortical thickness and each symptom dimension score. Compared to the healthy controls, the OCD patients had statistically significant reduction in cortical thickness in the cluster that contained the left superior temporal gyrus and posterior insular cortex (p < .05, corrected); no areas of the brain had significantly greater cortical thickness. Negative correlation was also found between cortical thickness and 鈥渃leaning鈥?dimension scores in the left postcentral and right superior parietal gyri. The present results suggest that cortical thinning in the region that contains the left superior temporal gyrus and posterior insula may underlie pathophysiology of OCD and that discrete neural systems may mediate the 鈥渃leaning鈥?symptom dimension.