Retrospective analysis of hemodialyzed diabetic patients in Japan
- 作者：Takei ; Izumi ; Yamauchi ; Akira ; Nakamoto ; Shinya ; Suzuki ; Hiromichi ; Saruta ; Takao
- 关键词：Non-insulin dependent diabetes ; End stage renal disease ; Hemodialyzed ; First visit proteinuria ; Non-compliance
- 刊名：Diabetes Research and Clinical Practice
- 出版年：1995
- 期刊代码：78_01688227
- 类别：med
- 出版时间：September, 1995
- 卷：29
- 期：3
- 页码：173-177
- 文件大小：403 K
摘要
We retrospectively analyzed the courses of 37 non-insulin dependent diabetics (hemodialyzed:HD group) with end-stage renal disease (ESRD), to identify factors predisposing to renal failure. The factors analyzed were: diabetic (non-proliferative and proliferative) retinopathy, family histories of diabetes and hypertension, smoking, dyslipidemia, first examination proteinuria and non-compliance. These factors were statistically compared in 37 NIDDM without renal failure (non-HD group). There were no significant differences in age or duration of diabetes between the two groups. Significant differences (P < 0.001) were, however, recognized in diabetic proliferative retinopathy and hypertension between the two groups. Hypertension was present in (97.2%) HD patients and in (58.3%) non-HD patients. A family history of hypertension was recognized in HD (43.2%) and in (21.2%) non-HD (P < 0.05). Differences were recognized in HDL-cholesterol, LDL-cholesterol and TG levels (38.2 ± 12.5 mg/dl and 56.7 ± 18.5 mg/dl, 140.4 ± 57.1 mg/dl and 115.6 ± 33.6 mg/dl, 169.9 ± 89.4 mg/dl and 115.7 ± 75.1 mg/dl, in HD and non-HD, respectively,P < 0.05). First visit proteinuria was found in all HD patients, and in (17.6%) non-HD. The difference in previous treatment refusal, for 7 or more years, was significant with (58.9%) HD patients and only (4.0%) non-HD patients (P < 0.001) having a history of prolonged non-compliance with diabetic treatment. Diabetic retinopathy, non-proliferative and proliferative, hypertension and a family history of hypertension, elevated triglyceride and LDL-cholesterol, low HDL-cholesterol, first visit proteinuria, and prolonged non-compliance correlated with progression to ESRD. We advocate expanding diabetic education to include prevention of complications such as diabetic nephropathy.