The capsule biosynthetic locus of Pasteurella multocida A:1
- 作者：Chung ; Jing Yeng ; Zhang ; Yamei ; Adler ; Ben
- 关键词：Pasteurella multocida ; Capsule ; Genetic locus ; Virulence
- 刊名：FEMS Microbiology Letters
- 出版年：1998
- 期刊代码：34_03781097
- 类别：imm
- 出版时间：September 15, 1998
- 卷：166
- 期：2
- 页码：289-296
- 文件大小：706 K
摘要
Pasteurella multocida is the aetiological agent of fowl cholera, bovine haemorrhagic septicaemia and atrophic rhinitis in pigs. Many strains of P. multocida express a capsule on their surface. However, nothing is known about the capsule biosynthetic locus in P. multocida although the capsule has been implicated as a virulence factor. The entire capsule locus of P. multocida A:1 was cloned and sequenced. The locus is divided into three regions. Region 1 comprises four ORFs which are involved in the transport of the capsule polysaccharide to the surface. Region 2 comprises five ORFs whose postulated protein products are involved in the biosynthesis of the polysaccharide capsule. Region 3 comprises two ORFs whose postulated products show similarity to proteins that are involved in the phospholipid substitution of the polysaccharide capsule.