Intracerebroventricular administration of neuronostatin delays gastric emptying and gastrointestinal transit in mice

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• 作者：Shu-Fang Su¹ ; Ai-Min Yang¹ ; Shao-Bin Yang ; Ning-Bo Wang ; Song-Song Lu ; Hui-Hui Wang ; Qiang Chen ; ^{chenq@lzu.edu.cn}
• 关键词：Neuronostatin ; Gastric emptying ; Gastrointestinal transit ; Central melanocortin system ; Opioid system
• 刊名：Peptides
• 出版年：2012
• 期刊代码：59_01969781
• 类别：neu
• 出版时间：May, 2012
• 卷：35
• 期：1
• 页码：31-35
• 文件大小：620 K

摘要

Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gastrointestinal transit were investigated. The results indicated that intracerebroventricular (i.c.v.) administration of neuronostatin (1, 5, 10 or 20 nmol/mouse) delayed gastric emptying and gastrointestinal transit in a dose-related manner in mice. The effects were significantly reversed by melanocortin 3/4 receptor antagonist SHU9119 or classical opioid receptor antagonist naloxone, suggesting that the central melanocortin system and opioid system may be involved in the gastrointestinal effects elicited by i.c.v. administration of neuronostatin. In addition, we found that C-terminal amidation modification of neuronostatin is essential to exert its gastrointestinal effects. These results indicated that neuronostatin may play an important role in regulating gastrointestinal function.