Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

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• 作者：Zhe Yan ; Yang Liu ; Hui Huang ; ^{huanghui11@yahoo.com}
• 关键词：Type 2 diabetes ; HbA1c ; Lipid ratio ; Cardiovascular disease
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2012
• 期刊代码：pca68_19957645
• 类别：med
• 出版时间：June, 2012
• 卷：5
• 期：6
• 页码：469-471
• 文件大小：243 K

摘要

Objective

To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin (HbA_1c).

Methods

Samples were collected from 128 type 2 diabetic patients (aged 19-90 years; male 72, female 56). The sera were analyzed for HbA_1c, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to the HbA_1c level, the patients were divided into three groups, group A (HbA_1c <7%, n=31), group B (7%猢紿bA_1c猢?0%, n=48), and group C (HbA_1c >10%, n=49). The correlation of HbA_1c with lipid ratios & individual lipid indexes were analyzed.

Results

With the increased level of HbA_1c, LDL-C had a significantly increasing trend (P<0.05); whereas TC went up with the increased HbA_1c, without any significant differences between three groups. There was no significant correlation between HbA_1c and TG or HDL-C. With the increased level of HbA_1c, TC/HDL-C, LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid.

Conclusions

LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.