Amperometric glucose sensor based on enhanced catalytic reduction of oxygen using glucose oxidase adsorbed onto core-shell Fe₃O₄@silica@Au magnetic nanoparticles

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• 作者：Ai-Jun Wang^a ; ^c ; Yong-Fang Li^b ; Zhong-Hua Li^c ; Jiu-Ju Feng^a ; ^c ; ^{jjfengnju@gmail.com} ; Yan-Li Sun^c ; Jian-Rong Chen^a
• 关键词：Fe3O4@silica@Au nanoparticles ; Glucose biosensor ; Electron transfer
• 刊名：Materials Science and Engineering ; C
• 出版年：2012
• 期刊代码：63_09284931
• 类别：ms
• 出版时间：1 August, 2012
• 卷：32
• 期：6
• 页码：1640-1647
• 文件大小：974 K

摘要

Monodisperse Fe₃O₄ magnetic nanoparticles (NPs) were prepared under facile solvothermal conditions and successively functionalized with silica and Au to form core/shell Fe₃O₄@silica@Au NPs. Furthermore, the samples were used as matrix to construct a glucose sensor based on glucose oxidase (GOD). The immobilized GOD retained its bioactivity with high protein load of 3.92 脳 10^鈭?#xA0;9 mol路cm^鈭?#xA0;2, and exhibited a surface-controlled quasi-reversible redox reaction, with a fast heterogeneous electron transfer rate of 7.98 卤 0.6 s^鈭?#xA0;1. The glucose biosensor showed a broad linear range up to 3.97 mM with high sensitivity of 62.45 渭A路mM^鈭?#xA0;1 cm^鈭?#xA0;2 and fast response (less than 5 s).