Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

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• 作者：Juan Zou^a ; ^b ; Jing Jiang^c ; Yan-Yan Diao^c ; Li-Bin Yang^a ; Jin Huang^c ; Hong-Lin Li^c ; Xue Du^a ; Wei-Lie Xiao^a ; ^{xwl@mail.kib.ac.cn} ; Jian-Xin Pu^a ; Han-Dong Sun^a ; ^{hdsun@mail.kib.ac.cn}
• 关键词：Schisandra glaucescens ; Schisandraceae ; Cycloartane triterpenoid ; FXR agonistic and antagonistic effects
• 刊名：Fitoterapia
• 出版年：2012
• 期刊代码：35_0367326x
• 类别：ch
• 出版时间：July, 2012
• 卷：83
• 期：5
• 页码：926-931
• 文件大小：813 K

摘要

Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC₅₀ of 1.50 渭M.