Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K⁺ channels

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• 作者：Dong ; Deli ; Duan ; Yanjun ; Guo ; Jiqing ; Roach ; Dan E. ; Swirp ; Shauni L. ; Wang ; Li ; Lees-Miller ; J.P. ; et. al.
• 关键词：K-channel ; Repolarization ; Sudden death ; Tau₁ ; relates to the I_Kslow component ; Tau₂ ; relates to the I_tos component ; Tau₃ ; relates to the I_tof component ; TG ; transgene ; TGCsA ; transgene tre
• 刊名：Cardiovascular Research
• 出版年：2003
• 期刊代码：48_00086363
• 类别：med
• 出版时间：February 1, 2003
• 卷：57
• 期：2
• 页码：320-332
• 文件大小：1.15 M

摘要

Background: Overexpression of calcineurin in transgenic (TG) mice results in cardiac hypertrophy and unexpected deaths. Methods and results: None of the TG survived beyond 24 weeks (n