An efficient synthesis of substituted cytosines and purines under focused microwave irradiation

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• 作者：Ling-Kuen Huang ; Yen-Chih Cherng ; Yann-Ru Cheng ; Jing-Pei Jang ; Yi-Ling Chao ; Yie-Jia Cherng
• 关键词：Nucleophilic displacement ; Focused microwave irradiation ; Cytosine ; Purine
• 刊名：Tetrahedron
• 出版年：2007
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：11 June 2007
• 卷：63
• 期：24
• 页码：5323-5327
• 文件大小：158 K

摘要

A rapid nucleophilic displacement reaction of 6-chloropurine, 2-amino-6-chloropurine and 5-bromocytosine with various nucleophiles under focused microwave irradiation is described. Using this method, the desired products were obtained with the yields up to 99%in a short reaction time.