Nitric oxide synthase inhibitor attenuates the anorexigenic effect of corticotropin-releasing hormone in neonatal chicks

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• 作者：Md. Sakirul Islam Khan ; Yasunori Nakano ; Tetsuya Tachibana ; Hiroshi Ueda
• 关键词：Corticotropin-releasing hormone ; Feeding ; Intracerebroventricular injection ; N^G-nitro-l-arginine methyl ester ; Neonatal chicks ; Neuropeptide Y ; Nitric oxide
• 刊名：Comparative Biochemistry and Physiology - Part A ; Molecular & Integrative Physiology
• 出版年：2008
• 期刊代码：23_10956433
• 类别：abs
• 出版时间：March 2008
• 卷：149
• 期：3
• 页码：325-329
• 文件大小：420 K

摘要

Nitric oxide (NO) is known as an orexigenic factor in the brain of mammals and mediates the feeding-stimulatory effect of other factors such as neuropeptide Y (NPY). In neonatal chicks, however, we recently reported that NO might have an anorexigenic effect and suggested that the feeding-regulatory mechanism in chicks might be different from that in mammals regarding NO. In the present study, we investigated the involvement of NO in the effect of other orexigenic and anorexigenic factors in neonatal chicks. Intracerebroventricular co-injection of N^G-nitro-l-arginine methyl ester (l-NAME), a NO synthase inhibitor, did not affect NPY- and prolactin-releasing peptide-induced feeding behavior. On the other hand, the co-injection of l-NAME significantly attenuated the anorexigenic effect of corticotropin-releasing hormone (CRH). The anorexigenic effects of glucagon-like peptide-1, alpha-melanocyte-stimulating hormone and ghrelin were not affected by the l-NAME treatment. These results suggest that NO might mediate the anorexigenic effect of CRH in the brain of neonatal chicks.