Protection of T cells from radiation-induced apoptosis by Cepharanthin®
- 作者：Oyaizu ; Haruki ; Adachi ; Yasushi ; Yasumizu ; Ryoji ; Ono ; Minoru ; Ikebukuro ; Kazuya ; Fukuhara ; Shirou ; et. al.
- 关键词：Cepharanthin ; Mitochondrial transmembrane potential (Δ ; ψ ; m) ; Radiation ; Apoptosis
- 刊名：International Immunopharmacology
- 出版年：2001
- 期刊代码：123_15675769
- 类别：med
- 出版时间：November, 2001
- 卷：1
- 期：12
- 页码：2091-2099
- 文件大小：245 K
摘要
Cepharanthin® (CE) is a medicine that contains several biscoclaurine alkaloids. We examined the effects of CE on radiation-induced T cell apoptosis. Radiation induced apoptosis on T cells in a dose-dependent manner, while CE inhibited radiation-induced apoptosis. CE also attenuated the cytotoxic effects of radiation on the proliferative response of T cells. CE inhibited not only the loss of mitochondrial transmembrane potential but also the activation of caspase 3 in irradiated T cells. Radiation plus CE induced the up-regulation of Bax and the down-regulation of Bcl-2 in T cells in comparison with radiation alone. These results suggest that CE inhibits the signal transduction pathway of apoptosis induced by radiation, regardless of the expression of Bcl-2 or Bax.