Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents
- 作者：Ping Liu ; Shaolong Zhu ; Peng Li ; Weijie Xie ; Yongsheng Jin ; Qingyan Sun ; Qiuye Wu ; Peng Sun ; Yingjun Zhang ; Xiaohong Yang ; Yuanying Jiang ; Dazhi Zhang
- 关键词：Hydrophobic polyelectrolyte ; Polymer– ; surfactant mixtures ; Associations ; Viscosity properties ; Cellulose derivatives ; Enhanced oil recovery
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：1 June 2008
- 卷：18
- 期：11
- 页码：3261-3265
- 文件大小：130 K
摘要
A series of 1-(substituted biaryloxy)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol were synthesized and their antifungal activities were evaluated against eight human pathogenic fungi in vitro. Seventeen compounds showed activity 4- to 64-fold higher than voriconazole against Candida albicans. SAR clearly suggested that introduction of a biaryloxy side chain greatly enhanced the antifungal activity of triazole analogs against Candida species.