Altered protein expression in endometrial carcinogenesis

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• 作者：Tatsuo Yoshizaki ; Takayuki Enomoto ; Ryuichi Nakashima ; Yutaka Ueda ; Hiroyuki Kanao ; Kiyoshi Yoshino ; Masahiro Fukumoto ; Yoshihiro Yoneda ; Gregory S. Buzard and Yuji Murata
• 关键词：Endometrial carcinoma ; Proteomics ; SELDI-TOF-MS
• 刊名：Cancer Letters
• 出版年：2005
• 期刊代码：44_03043835
• 类别：med
• 出版时间：2005
• 卷：226
• 期：2
• 页码：101-106
• 文件大小：192 K

摘要

We have discovered several protein biomarkers that are altered during carcinogenesis of the human uterine endometrium. Proteins prepared from 19 endometrial carcinomas (Group A), and 20 normal endometria obtained from benign gynecological conditions (Group B), were investigated by Surface Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS). Two proteins, EC1 and EC2, were consistently expressed differentially. EC1 had an increased level of expression in carcinomas (P<0.001), while EC2 was expressed at a lower level (P