The role of kinin B₁ in the plasma extravasation of carrageenin-induced pleurisy

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• 作者：Hayashi ; Izumi ; Amano ; Hideki ; Ishihara ; Keiko ; Kumagai ; Yuji ; Yoshimura ; Hirokuni ; Majima ; Masataka
• 关键词：Des-Arg⁹-bradykinin ; Kinin B₁ receptor ; Pleurisy ; Plasma extravasation ; Brown Norway Katholiek rat
• 刊名：Life Sciences
• 出版年：2002
• 期刊代码：62_00243205
• 类别：imm
• 出版时间：January 11, 2002
• 卷：70
• 期：8
• 页码：937-949
• 文件大小：151 K

摘要

The role of des-Arg⁹-bradykinin (des-Arg⁹-BK) and kinin B₁ receptor in the plasma extravasation of rat carrageenin-induced pleurisy was investigated employing B₁ receptor agonist and antagonists and kininogen-deficient rats. Expression of the B₁ receptor mRNA in pleura was induced from 3 to 5 h after the injection of carrageenin into the pleural cavity of Sprague-Dawley rats. Exogenous injection of des-Arg⁹-BK into the pleural cavity provoked a significant increase in plasma extravasation in 5 h carrageenin-induced pleurisy, but not in 20 min kaolin-induced pleurisy. The level of immunoreactive des-Arg⁹-BK in the exudate of 5 h carrageenin-induced pleurisy was higher than that of bradykinin (BK). Administration of the B₁ receptor antagonists, des-Arg⁹-[Leu⁸]-BK or des-Arg⁹-d-Arg-[Hyp³, Thi⁵,d-Tic⁷,Oic⁸]-BK significantly reduced the exudation rate. However, intrapleural administration of des-Arg⁹-BK to plasma kininogen-deficient, Brown Norway-Katholiek rats did not result in a further increase in the plasma extravasation. In conclusion, endogenously generated des-Arg⁹-BK could contribute to the plasma extravasation in carrageenin-induced pleurisy via mediation of the inducible B₁ receptor.