Halothane sensitizes the canine heart to pharmacological I_Kr blockade

详细信息	查看全文 | 推荐本文 |

• 作者：Takahara ; Akira ; Sugiyama ; Atsushi ; Satoh ; Yoshioki ; Wang ; Kai ; Honsho ; Sachiko ; Hashimoto ; Keitaro
• 关键词：Halothane ; Pentobarbital ; Sematilide ; Ventricular repolarization
• 刊名：European Journal of Pharmacology
• 出版年：2005
• 期刊代码：24_00142999
• 类别：neu
• 出版时间：January 10, 2005
• 卷：507
• 期：1-3
• 页码：169-177
• 文件大小：276 K

摘要

The effects of halothane and pentobarbital on the cardiovascular system were compared using the in vivo canine models. The ventricular repolarization process was longer under the halothane-anesthesia than pentobarbital-anesthesia. Intravenous administration of a selective blocker of rapidly activating delayed rectifier K⁺ currents (I_Kr) sematilide prolonged the ventricular repolarization period without affecting the intraventricular conduction under both anesthesia; however, the potency was about 1.5-folds greater under the halothane-anesthesia than pentobarbital-anesthesia. These results suggest that halothane can more effectively sensitize the heart to pharmacological I_Kr blockade, resulting in the excessive QT interval prolongation. Thus, the halothane-anesthetized canine model can be useful for predicting the in vivo I_Kr blocking property of new drugs.