Synthetic studies toward neovibsanins A and B: construction of the neovibsanin core utilizing palladium(0)-catalyzed carbonylative cyclization with carbon monoxide

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• 作者：Tomoyuki Esumi ; Ming Zhao ; Taishi Kawakami ; Mayuna Fukumoto ; Masao Toyota ; Yoshiyasu Fukuyama
• 关键词：Neovibsanins A and B ; Pd-catalyzed carbonylative cyclization ; Neurotrophic activity
• 刊名：Tetrahedron Letters
• 出版年：2008
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：21 April 2008
• 卷：49
• 期：17
• 页码：2692-2696
• 文件大小：136 K

摘要

The core A-ring of neovibsanins A (1) and B (2), which are potent neurotrophic agents isolated from the leaves of Viburnum awabuki, have been effectively constructed by the intramolecular palladium(0)-catalyzed carbonylative cyclization of alkenyl iodide with carbon monoxide.