Can metabolic syndrome predict the vulnerable plaque in patients with stable angina pectoris? Virtual histology-intravascular ultrasound analysis

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• 作者：Min Goo Lee ; MD ; Myung Ho Jeong ; MD ; PhD ; ^{myungho@chollian.net} ; ^{myungho@chol.com} ; Dong Han Kim ; MD ; Ki Hong Lee ; MD ; Keun Ho Park ; MD ; Doo Sun Sim ; MD ; Nam Sik Yoon ; MD ; Hyun Ju Yoon ; MD ; Kye Hun Kim ; MD ; Hyung Wook Park ; MD ; Young Joon Hong ; MD ; Ju Han Kim ; MD ; Youngkeun Ahn ; MD ; Jeong Gwan Cho ; MD ; Jong Chun Park ; MD ; Jung Chaee Kang ; MD
• 关键词：Vulnerable plaque ; Metabolic syndrome ; Angina pectoris
• 刊名：Journal of Cardiology
• 出版年：2012
• 期刊代码：P90_09145087
• 类别：med
• 出版时间：May, 2012
• 卷：59
• 期：3
• 页码：266-274
• 文件大小：495 K

摘要

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Summary

Background

Vulnerable plaque in coronary artery can progress to plaque rupture and thrombosis, and have a strong potential to induce acute coronary syndrome. Many studies have demonstrated that metabolic syndrome (MetS) is associated with increased risk for cardiovascular diseases and related mortalities.

Methods

From September 2007 to June 2010, a total of 239 patients with stable angina pectoris (SAP) who underwent coronary angiogram and intravascular ultrasound (IVUS) were categorized into two groups: MetS group (n = 100, 56 men, 64.7 卤 9.5 years) and non-MetS group (n = 139, 98 men, 60.2 卤 8.4 years).

Results

MetS group showed more frequent multivessel involvement (p = 0.026) and had more distal target vessel in coronary artery (p = 0.005) than non-MetS group, but IVUS findings showed no significant difference between the two groups. In addition, low high-density lipoprotein (HDL) cholesterol level as the criteria of MetS was observed in virtual histology (VH)-derived thin cap fibroatheroma (TCFA) group more than stable plaque group (p = 0.020), but the prevalence of MetS and other components of MetS were not different between the two groups. Multivariate analysis using logistic regression for the presence of VH-derived TCFA showed that the independent predictor is the low HDL cholesterol level (odds ratio = 3.563, 95%confidence interval = 1.370-9.269, p = 0.009).

Conclusions

The presence of MetS was not associated with VH-derived TCFA in patients with SAP.