Continuing evolution of H9 influenza viruses in Korean poultry
- 作者：Youn-Jeong Lee ; Jin-Young Shin ; Min-Suk Song ; Young-Min Lee ; Jun-Gu Choi ; Eun-Kyoung Lee ; Ok-Mi Jeong ; Haan-Woo Sung ; Jae-Hong ; Kim ; Yong-Kuk Kwon ; et al.
- 关键词：Avian influenza ; H9N2 ; H9N8 ; Reassortment ; Korea
- 刊名：Virology
- 出版年：2007
- 期刊代码：108_00426822
- 类别：imm
- 出版时间：15 March 2007
- 卷：359
- 期：2
- 页码：313-323
- 文件大小：751 K
摘要
We analyzed the evolution of H9 influenza viruses isolated from Korean chicken farms from 2002 to 2004. Korean H9 viruses formed two antigenically distinct groups: those isolated from 1996 to mid-2003, and those isolated from late 2003 through 2004. Most of the 2004 isolates showed greater cross-reactivity with the second group than with the first group. Phylogenetic analysis of the 12 viruses studied revealed three genotypes of H9N2 viruses and showed that reassortment had occurred. One isolate, Ck/Kor/164/04, belonged to the H9N8 subtype. Its HA and PB1 genes were similar to those of the H9N2 viruses, but its other genes were closely related to H3N8 viruses. This report is the first (to our knowledge) of H9N8 infection in this host. The pathogenicity of the early isolates altered due to antigenic drift and reassortment, leading to H9 avian influenza viruses in Korea that potentially can expand their host range to mammalians.