Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

详细信息	查看全文 | 推荐本文 |

• 作者：Christa E. Mü ; ller ; Jamshed Iqbal ; Younis Baqi ; Herbert Zimmermann ; Anita Rö ; llich ; Holger Stephan
• 关键词：P2 receptors ; NTPDases
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 December 2006
• 卷：16
• 期：23
• 页码：5943-5947
• 文件大小：235 K

摘要

Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K₆H₂[TiW₁₁CoO₄₀], exhibiting K_i values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH₄)₁₈[NaSb₉W₂₁O₈₆], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.