Two generation reproduction and teratogenicity studies of feeding quinocetone fed to Wistar rats

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• 作者：Xu Wang^a ; ¹ ; Wei Zhang^a ; ¹ ; Yu-Lian Wang^a ; Awais Ihsan^a ; ^b ; Meng-Hong Dai^a ; Ling-Li Huang^a ; Dong-Mei Chen^a ; Yan-Fei Tao^a ; Da-Peng Peng^a ; Zhen-Li Liu^a ; Zong-Hui Yuan^a ; ^{wangxu@mail.hzau.edu.cn} ; ^{yuan5802@mail.hzau.edu.cn}
• 关键词：ANOVA ; analysis of variance ; b.w. ; body weight ; GD ; gestational day ; H&E ; hematoxylin and eosin ; QdNOs ; quinoxaline-1 ; 4-dioxides ; ROS ; reactive oxygen species
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：May, 2012
• 卷：50
• 期：5
• 页码：1600-1609
• 文件大小：1039 K

摘要

To investigate the reproductive toxicity and teratogenic potential of quinocetone, a growth promoting agent, Wistar rats were fed different diets containing 0, 50, 300 and 1800 mg/kg quinocetone or 300 mg/kg olaquindox. Groups of 15 males and 30 females (F₀) were fed through a 10-week prebreed period as well as during mating, gestation, parturition and lactation. At weaning, 12 males and 24 females of F₁ generation weanlings per group were selected randomly as parents for F₂ generation. Selected F₁ weanlings were exposed to the same diet and treatment as their parents. At the highest quinocetone group, body weights in F₀ and F₁ rats, fetal body weight on day 21 after birth and number of viable fetuses in F₀ and F₁ generation significantly decreased. In teratogenicity study, groups of 12 males and 24 females were fed with the same diets through a 12-week prebreed period and matting periods. Pregnant rats were subjected to cesarean section on GD 20 for teratogenic examination. At the highest quinocetone group, body weights and feed efficiency, fetal body lengths, tail lengths, litter weights and number of viable fetuses significantly decreased. The NOAEL for reproduction/development of quinocetone for rats was estimated to be 300 mg/kg diet.