A mouse model of depression induced by repeated corticosterone injections
- 作者：Yunan Zhao ; Ru Ma ; Jia Shen ; Hui Su ; Dongming Xing ; Lijun Du
- 关键词：Corticosterone ; Depression ; Animal model ; Tyrosine hydroxylase ; Stress ; (Mouse)
- 刊名：European Journal of Pharmacology
- 出版年：2008
- 期刊代码：24_00142999
- 类别：neu
- 出版时间：26 February 2008
- 卷：581
- 期：1-2
- 页码：113-120
- 文件大小：284 K
摘要
A rat model of depression has been recently developed by exogenous corticosterone administration. In this study, we further determined whether corticosterone administration also increased depression-like behavior in mice and explored the brain biochemical consequences of exposure to this administration paradigm. Mice received repeated injections of vehicle and 20 mg/kg of corticosterone for 1, 3 and 5 weeks, and then were subjected to the forced-swim and tail suspension tests. The results showed that repeated corticosterone injections increased immobility behavior in the forced-swim and tail suspension tests in a time-dependent manner. Meanwhile, this injection paradigm produced a time-related effect on tyrosine hydroxylase (TH) levels in the hippocampus of mice. These results are consistent with correlations in stress-induced depression models, and suggest that the repeated corticosterone injection paradigm provides a useful and reliable mouse model within which to further study the role of stress and glucocorticoids in depressive illness, as well as screen for antidepressants or preventive drugs.