Cellulose tris(3,5-dichlorophenylcarbamate) immobilised on silica: A novel chiral stationary phase for resolution of enantiomers
- 作者：Tong Zhang ; Dung Nguyen ; Pilar Franco ; Yutaka Isobe ; Takashi Michishita ; Tatsushi Murakami
- 关键词：CHIRALPAK IC ; Cellulose tris(3 ; 5-dichlorophenylcarbamate) ; Immobilised polysaccharide-based chiral stationary phases ; Enantiomeric resolution by liquid chromatography
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2008
- 期刊代码：65_07317085
- 类别：ch
- 出版时间：14 April 2008
- 卷：46
- 期：5
- 页码：882-891
- 文件大小：840 K
摘要
CHIRALPAK IC is a new chiral stationary phase (CSP) made by immobilising cellulose tris(3,5-dichlorophenylcarbamate) on silica gel. The chiral selector is distinct from any other commercially available polysaccharide-based CSPs. Apart from its compatibility with the whole series of solvents; this CSP is able to operate under various chromatographic conditions and bring about new characteristics in enantiomeric recognition. It can afford many large and specific enantiomeric separations. It exhibits complementary properties with regard to the existing immobilised chiral packing materials of the same category.