摘要
Three new phenolic constituents, itolide A (trong class="boldFont">1trong>), itolide B (trong class="boldFont">2trong>), itoside P (trong class="boldFont">3trong>), and 1D-3-deoxy-3-hydroxymethyl-myo-inositol (trong class="boldFont">4trong>), which is described herein for the first time as a natural product, were isolated along with four other known compounds (trong class="boldFont">5trong> to trong class="boldFont">8trong>) from the methanol extract of the seeds of Itoa orientalis Hemsl by the activity-guided fractionation. Their structures were determined by spectroscopic means. Compounds trong class="boldFont">1trong> to trong class="boldFont">8trong> exhibited antifungal activities against Sclerotium rolfsii with IC50 values ranging from 60.12 to 240.00 渭M and against Rhizoctonia solani with IC50 values ranging from 45.34 to 233.14 渭M, respectively, and compounds trong class="boldFont">1trong>, trong class="boldFont">2trong>, trong class="boldFont">5trong> exhibited cytotoxic activity against Tn5B1-4 insect cell line with EC50 values of 203.68, 93.41 and 40.37 渭M, respectively.