Recent measurements of inclusive and semi-inclusive deep inelastic scattering in electron-proton collisions at HERA are reviewed. These measurements are used to determine the parton distribution functions (PDFs) of the proton, a necessary input to almost all theory predictions for hadron colliders. An introduction to the PDF determination with an emphasis on HERA PDFs is presented. Theory predictions based on HERAPDF are compared to a selection of recent LHC and Tevatron measurements. The impact of jet and charm production measurements in DIS at HERA on the PDFs is discussed.