IRF7, a functional factor associates with systemic lupus erythematosus

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• 作者：Wang-Dong Xu ; Yu-Jing Zhang ; Ke Xu ; Yu Zhai ; Bao-Zhu Li ; Hai-Feng Pan ; Dong-Qing Ye ; ^{ydq@ahmu.edu.cn} ; ^{ydqahmu@gmail.com}
• 关键词：Interferon regulatory factor 7 ; Systemic lupus erythematosus ; Autoimmune
• 刊名：Cytokine
• 出版年：2012
• 期刊代码：97_10434666
• 类别：imm
• 出版时间：June, 2012
• 卷：58
• 期：3
• 页码：317-320
• 文件大小：171 K

摘要

Systemic lupus erythematosus is an autoimmune disease attributing to a combination of genetic and environmental factors. Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-伪, which can be regulated by IFN regulatory factor 7 (IRF7). Single nucleotide polymorphisms (SNPs) near/in IRF7 have been substantiated related to onset of SLE, moreover, regulation of IRF7 expression/function has been found important in SLE. Therefore, we will discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in.