Cytotoxic sesquiterpene lactones from Vernonia bockiana

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• 作者：Shang-Gao LIAO ; Zhen WANG ; Jing LI ; Ying LIU ; Yue-Ting LI ; Li-Juan ZHANG ; Qing-De LONG ; Yong-Lin WANG ; ^{ylwang_gmc@163.com}
• 关键词：Vernonia bockiana ; Compositae ; Sesquiterpene lactone ; Anti-tumor activity
• 刊名：Chinese Journal of Natural Medicines
• 出版年：2012
• 期刊代码：P72_18755364
• 类别：med
• 出版时间：May, 2012
• 卷：10
• 期：3
• 页码：230-233
• 文件大小：171 K

摘要

Aim

To investigate antitumor compounds from Vernonia bockiana.

Methods

The compounds were isolated by column chromatography and preparative HPLC. Their structures were elucidated by ¹H and ¹³C NMR spectroscopic methods and MS experiments. The antitumor activity was evaluated by testing their cytotoxicity against the human promyelomonocyte leukemic cell line HL-60 by the MTT method.

Results

Six sesquiterpene lactones, 8伪-(4-hydroxymethacryloyloxy)-10伪-hydroxy-13-methoxyhirsutinolide (1), 8伪-methacryloyloxy-10伪-hydroxy-13-O-methylhirsutinolide (2), piptocarphin A (3), 8伪-[4-hydroxymethacryloyloxy]-10伪-hydroxyhisutinolide-13-O-acetate (4), piptocarphin F (5), and 8伪-acetoxy-10伪-hydroxy-13-O-methylhirsutinolide (6), and one known inone glycoside, saussureosides B (7), were isolated from the whole plant of V. bockiana. The six sesquiterpene lactones showed cytotoxic activity (IC₅₀ 3.87-12.5 渭mol路L^鈭?) against the human leukemic cell line HL-60 while the inone glycoside 7 was inactive in the test.

Conclusion

Compounds 1, 2, 6, and 7 were obtained for the first time from this plant; The sesquiterpene lactones present in V. bockiana were active as antitumor agents against the human leukemic cell line HL-60.